{"id":9639,"date":"2017-06-13T14:39:15","date_gmt":"2017-06-13T14:39:15","guid":{"rendered":"http:\/\/www.fetaldna.it\/metodologia-inipt\/"},"modified":"2022-03-04T09:38:55","modified_gmt":"2022-03-04T09:38:55","slug":"nipt-metodologia-inipt","status":"publish","type":"page","link":"https:\/\/www.fetaldna.it\/en\/nipt-metodologia-inipt\/","title":{"rendered":"FETALDNA iNIPT™"},"content":{"rendered":"

[vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1642093547936{padding-top: 100px !important;padding-bottom: 50px !important;background-image: url(https:\/\/www.fetaldna.it\/wp-content\/uploads\/2022\/01\/Header_inipt.png?id=13439) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column css=”.vc_custom_1642010227194{padding-top: 100px !important;padding-bottom: 100px !important;}”][\/vc_column][\/vc_row][vc_row 0=”” softing_row_prepad=”ptb-30″][vc_column 0=””][vc_custom_heading text=”From NIPT to iNIPT: innovation in prenatal screening” font_container=”tag:h2|text_align:center” use_theme_fonts=”yes”][vc_column_text]<\/p>\n

Beyond Massive Parallel Sequencing, Massive Parallel and Digital Sequencing is now the state-of-the-art.<\/h3>\n

[\/vc_column_text][vc_column_text css=”.vc_custom_1646347078622{padding-top: 3% !important;}”]The technology that makes FetalDNA unique in the fetal DNA test landscape is iNIPTTM<\/sup>, developed within the Genetics Laboratory of the Altamedica Healtcare Center in Rome.<\/p>\n

It is an integrated platform for the latest generation of genetic sequencing<\/strong>, which involves the synergistic use of technologies of massive DNA sequencing (Next Generation Sequencing) and Digital PCR (Polymerase Chain Reaction).<\/p>\n

While the already known method of parallel massive sequencing allows the analysis of the entire genome, Digital PCR represents the possibility of investigating genetic mutations and anomalies with a sensitivity and reliability never achieved before.<\/p>\n

In addition, the use of proprietary bioinformatics analysis provides really high reliability in results<\/strong>.[\/vc_column_text][\/vc_column][\/vc_row][vc_row 0=””][vc_column 0=””][vc_column_text]<\/p>\n

Superiority of iNIPTTM<\/sup>
\nover traditional NIPT: scientific evidence<\/h3>\n

[\/vc_column_text][vc_column_text css=”.vc_custom_1646347209461{padding-top: 3% !important;}”]It should be noted that, beyond the excessive success rates declared by the traditional NIPT tests on the market for years, their real validity can only be established through Amniocentesis \/ CVS.<\/p>\n

During the period from September 2014 to September 2017, the Altamedica Center in Rome recorded 15,173<\/strong> invasive prenatal procedures related to Amniocentesis<\/strong> and CVS<\/strong>.<\/p>\n

In this large group, we selected 385 pregnancies<\/strong> in which a NIPT test reported a doubt in a chromosomal or subchromosomal abnormality or ultrasound scans revealed the suspicion of a chromosomal or genetic abnormality even if the NIPT test was negative for chromosomal pathology.<\/p>\n

This preclinical study showed that:[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” equal_height=”yes” content_placement=”middle” softing_row_prepad=”ptb-30″ css=”.vc_custom_1642091380162{background-color: #f2483e !important;}”][vc_column][vc_row_inner content_placement=”middle”][vc_column_inner width=”1\/2″ css=”.vc_custom_1642091516293{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;padding-top: 3% !important;padding-right: 3% !important;padding-bottom: 3% !important;padding-left: 3% !important;background-color: #ffffff !important;border-left-color: #f2483e !important;border-left-style: solid !important;border-right-color: #f2483e !important;border-right-style: solid !important;border-top-color: #f2483e !important;border-top-style: solid !important;border-bottom-color: #f2483e !important;border-bottom-style: solid !important;border-radius: 5px !important;}”][vc_column_text]The first group<\/strong> reported 197 women<\/strong> with a positive NIPT test<\/strong> who underwent an invasive prenatal examination (amniocentesis or CVS) to confirm the diagnosis (TAB 1).[\/vc_column_text][vc_single_image image=”11163″ img_size=”large” alignment=”center”][vc_column_text]False positives range from 10% to 84% (for microdeletions), 9.5% for T21 and 36.8% for T18, dPCR reduces to zero the false positive<\/strong> rate for fetal abnormalities of chromosome 18 and 21.<\/p>\n

Altamedica team performed the FetalDNA test preclinically | iNIPT™ technology to validate its accuracy compared to traditional NIPT.<\/strong>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″ css=”.vc_custom_1642091525232{border-top-width: 2px !important;border-right-width: 2px !important;border-bottom-width: 2px !important;border-left-width: 2px !important;padding-top: 3% !important;padding-right: 3% !important;padding-bottom: 3% !important;padding-left: 3% !important;background-color: #ffffff !important;border-left-color: #f2483e !important;border-left-style: solid !important;border-right-color: #f2483e !important;border-right-style: solid !important;border-top-color: #f2483e !important;border-top-style: solid !important;border-bottom-color: #f2483e !important;border-bottom-style: solid !important;border-radius: 5px !important;}”][vc_column_text]The second group<\/strong> included 188\u00a0 women<\/strong> who underwent invasive prenatal diagnosis after a negative NIPT test but there was an ultrasound suspicion of fetal chromosomal pathology\u00a0(TAB 2<\/strong><\/a>).<\/p>\n

[\/vc_column_text][vc_single_image image=”11168″ img_size=”large” alignment=”center”][vc_column_text]<\/p>\n

False negatives range from 5% to 10%, dPCR reduces the false negative rate<\/strong> for fetal abnormalities of chromosome 18 and 21 to zero.<\/p>\n

The Altamedica team executed the FetalDNA test | iNIPT ™ technology\u00a0preclinically in order to validate its accuracy compared to traditional NIPT.<\/strong>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row el_id=”tab2″][vc_column][vc_column_text]* Ultrasound Obstet Gynecol. 2017 Jun; 49(6):815-816. doi: 10.1002\/uog.17483.\u00a0<\/i>ISUOG updated consensus statement on the impact of cfDNA aneuploidy testing<\/i> on screening policies and prenatal ultrasound practice.\u00a0<\/i>S<\/i>alomon LJ, Alfirevic Z, Audibert F, Kagan KO, Paladini D, Yeo G, <\/i>Raine-Fenning N; ISUOG Clinical Standards Committee.\u00a0<\/i>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1642093547936{padding-top: 100px !important;padding-bottom: 50px !important;background-image: url(https:\/\/www.fetaldna.it\/wp-content\/uploads\/2022\/01\/Header_inipt.png?id=13439) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column css=”.vc_custom_1642010227194{padding-top: 100px !important;padding-bottom: 100px !important;}”][\/vc_column][\/vc_row][vc_row 0=”” softing_row_prepad=”ptb-30″][vc_column 0=””][vc_custom_heading text=”From NIPT to iNIPT: innovation in prenatal screening” font_container=”tag:h2|text_align:center” use_theme_fonts=”yes”][vc_column_text] Beyond Massive Parallel Sequencing, Massive Parallel and Digital Sequencing is now the state-of-the-art. [\/vc_column_text][vc_column_text css=”.vc_custom_1646347078622{padding-top: 3% !important;}”]The technology that makes FetalDNA…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"custom-page.php","meta":{"footnotes":""},"class_list":["post-9639","page","type-page","status-publish","hentry"," c-blog-1-item nt-post-class"],"yoast_head":"\nNIPT - metodologia innovativa iNIPT per screening prenatale - FetalDNA<\/title>\n<meta name=\"description\" content=\"La metodologia iNIPT supera la NIPT tradizionale, integrando il Sequenziamento massivo del DNA (NGS) con la Digital PCR. 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